Leftie here. I have a Lithgow Crossover LA101 in LH config. It is the only rifle in the safe that''s left handed.
Sure i am a little disadvantaged, but i have never been pulled up for a safety issue or caused a concern. I dont use my fore end arm to work the bolt, My dad taught me when i was a kid, to roll the rifle to the left while being down range and reach over with me shooting hand. Have been doing that for 30+ years,.
Safety's are the biggest pain the butt to use, however when i am on the farm, i leave the rifle with the mag loaded and bolt closed.. I only load a round when i am ready to take a shot. No need for safeties then.
I bought the LA101 because it was lefthanded and thought i really need a leftie rifle.. Would i buy another one, probably not..
I also shoot pistols and you get the same problem with mag releases, slide releases etc. You just learn to deal with it and look like a numpty