Well Bigrich it depends on what you are eventually going to use it for if its only dogs then a 22-250 is perfect
but if you want it for other things like larger pests then a 243 is a little of a better thing it is a very capable caliber
barrel life would be much the same give or take a couple of hundred rounds
Then you could take a look at what rifles you already have if there is any close to doing the same as the 243 then
the 22-250 might be the go but if you don't then the 243 would be a better choice
Then it comes down to what you are feeling in the heart and what you really want because both will take dogs
quiet effectively
Then if you are like me ''BOTH '' would be nice
Cheers